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Results of Other Medication on VIAGRA Sildenafil metabolism is principally mediated by CYP3A4 (significant route) and CYP2C9 (minor route). For that reason, inhibitors of these isoenzymes may perhaps lower sildenafil clearance and inducers of these isoenzymes may possibly boost sildenafil clearance.The most common Unintended effects of sildenafil a